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For Interventional Cardiologists

Your source of training and data to treat high-risk PCI, cardiogenic shock and right heart failure patients
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ACC/AHA Upgrades mAFP to Class 2a and Downgrades IABP and VA-ECMO to Class 3

The new Acute Coronary Syndrome (ACS) guidelines downgrade intra-aortic balloon pump (IABP) and venoarterial extracorporeal membrane oxygenation (VA-ECMO) to Class 3 due to no shown benefit, while microaxial intravascular flow pumps (mAFP), Impella®, is now Class 2a in patients with STEMI and severe or refractory cardiogenic shock.2

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Explore the DanGer Shock RCT

The guideline upgrade for Impella is based on evidence from the DanGer Shock RCT, published in the New England Journal of Medicine and the first AMI cardiogenic shock (AMICS) trial to achieve its primary survival endpoint.1,2

 

Final Results from the National Cardiogenic Shock Initiative (NCSI) Study Report Demonstrate Benefit of Early Impella Cardiac Unloading3

The final results of the physician-led NCSI Study demonstrate a 71% survival to discharge with greater than 90% native heart recovery when best practices are used, including placement of an Impella heart pump prior to revascularization (PCI).3

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Explore the Latest Presented Data From the National Cardiogenic Shock Initiative (NCSI) Study

  • 72%

    Survival3

  • >90%

    Native heart recovery at discharge3

NCSI Study is an independent, physician-led, national, multicenter initiative aimed at improving mortality in patients with AMI cardiogenic shock (AMICS).3 Based on the consistent finding of good survival outcomes with early hemodynamic support with Impella therapy from the IQ database and cVAD study, a best practices algorithm for the treatment of patients with AMICS was established. The NCSI Study algorithm includes identifying shock early, use of Impella therapy before PCI, reducing the use of inotropes and the use of invasive hemodynamic monitoring to aid in escalation and weaning.

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DanGer Shock Discussion with Jacob Møller at TCT 2024

Jacob Møller, M.D., and Chuck Simonton, M.D., discuss the DanGer Shock RCT and new data presented at TCT 2024.

 

Impella ECP™ Pivotal Study: First Results

Amir Kaki, M.D., describes the first results from the Impella ECP Pivotal Study.

Conditions & Therapies

Protected PCI

Learn more about effective hemodynamic support in elective and urgent high-risk PCI with the Impella® platform.

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AMI Cardiogenic Shock

Reverse the downward spiral of cardiogenic shock by identifying patients early, treating them with a proven protocol and following them with hemodynamic monitoring.

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Right Heart Failure

Learn how to identify right ventricular failure, review criteria for consideration of right-sided support, and access other resources to improve patient outcomes.

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Education and Resources

Explore case reviews, clinical data, ongoing studies, best practice resources, patient management tips and more

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Calculators and Tools

Access instant calculators for CPO/PAPI, heparin rate and AKI, and identify patients using the selection tool

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References

  1. Møller J, et al. (2024). Microaxial Flow Pump or Standard Care in Infarct-Related CS. N Engl J Med. DOI: 10.1056/NEJMoa2312572 
  2. Rao, SV, et al. (2025). ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients with Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Journal of the American College of Cardiology. https://pubmed.ncbi.nlm.nih.gov/40013746/ 
  3. Basir, B, et al. (2019). Improved Outcomes Associated with the use of Shock Protocols: Updates from the National Cardiogenic Shock Initiative. Wiley. DOI: 10 .1002 /ccd .28307

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