Cardiac and Vascular Surgeons
Resources to improve outcomes for surgical patients
Impella 5.5 with SmartAssist and Low Cardiac Output Syndrome (LCOS)
LCOS, a state of cardiogenic shock with a 10% incidence rate, has multiple definitions with a common determination of hemodynamic instability requiring pharmacological or mechanical support.
Preoperative Considerations for LCOS
Identifying certain risk factors that can contribute to LCOS may inform the decision on treatment options.
Independent Predictors of LCOS Using Stepwise Logistic Regression Analysis
Selecting the Appropriate MCS Device
Impella 5.5 with SmartAssist delivers full cardiac support with maximum unloading, allowing the heart to rest and recover.
Despite pharmacological support, 10.1% of adults undergoing cardiac surgery develop LCOS.1 LCOS increase the risk of postoperative mortality by 12- to 25-fold.2-6
The emergence of LCOS after cardiac surgery significantly increases length of intensive care unit (ICU) and hospital stay, 30-day readmission rates and costs of treatment.
The occurrence of LCOS after cardiac surgery decreases the rate of hospital discharge to home from 80% to 50%. Moreover, LCOS increases the risk-adjusted hospital cost by an average of $16,000.1
| Cardiac Surgery with LCOS | Cardiac Surgery without LCOS | P-Value | |
|---|---|---|---|
| Risk-adjusted hospital cost | $64K | $48K | <0.001 |
| Risk-adjusted length of stay | 10.1 days | 8.5 days | <0.001 |
| Risk-adjusted length of ICU stay | 5.5 days | 3.3 days | <0.001 |
| Provide myocardial rest | 16.6% | 13.9% | <0.001 |
| Discharged home | 50% | 80% | <0.001 |
Impella 5.5 with SmartAssist Clinically Demonstrated Improvement in Overall Survival
Data from the First 200 Patients Treated
Survival and Recovery by Indication
Sustained results in >3,700 patients
Survival and Recovery by Indication
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References
- Duncan, A. et al. (2022). J Thorac Cardiovasc Surg, 163(5), 1890-1898.e10
- Algarni, K. (2011), Ann Thorac Surg, 92(5), 1678-1684.
- Ding, W., et al. (2015), Int Heart J, 56(2), 144-149.
- Maganti, M., et al. (2005), Circulation, 112(9 suppl), 1448-1452.
- Maganti, M., et al. (2010), J Thorac Cardiovascular Surg, 140(4), 790-796.
- Sa, M., et al. (2012), Rev Bras Circ Cardiovasc, 27(2), 217-223.
NPS-1338